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2 @article{watts_architecture_2009,
3 title = {Architecture and secondary structure of an entire {HIV-1} {RNA} genome},
4 volume = {460},
5 copyright = {© 2009 Nature Publishing Group},
6 issn = {0028-0836},
7 url = {},
8 doi = {10.1038/nature08237},
9 abstract = {Single-stranded {RNA} viruses encompass broad classes of infectious agents and cause the common cold, cancer, {AIDS} and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic {RNA} structures. Most potential regulatory elements in viral {RNA} genomes are uncharacterized. Here we report the structure of an entire {HIV-1} genome at single nucleotide resolution using {SHAPE}, a high-throughput {RNA} analysis technology. The genome encodes protein structure at two levels. In addition to the correspondence between {RNA} and protein primary sequences, a correlation exists between high levels of {RNA} structure and sequences that encode inter-domain loops in {HIV} proteins. This correlation suggests that {RNA} structure modulates ribosome elongation to promote native protein folding. Some simple genome elements previously shown to be important, including the ribosomal gag-pol frameshift stem-loop, are components of larger {RNA} motifs. We also identify organizational principles for unstructured {RNA} regions, including splice site acceptors and hypervariable regions. These results emphasize that the {HIV-1} genome and, potentially, many coding {RNAs} are punctuated by previously unrecognized regulatory motifs and that extensive {RNA} structure constitutes an important component of the genetic code.},
10 language = {en},
11 number = {7256},
12 urldate = {2012-07-01},
13 journal = {Nature},
14 author = {Watts, Joseph M. and Dang, Kristen K. and Gorelick, Robert J. and Leonard, Christopher W. and Jr, Julian W. Bess and Swanstrom, Ronald and Burch, Christina L. and Weeks, Kevin M.},
15 month = aug,
16 year = {2009},
17 keywords = {astronomy, astrophysics, biochemistry, bioinformatics, biology, biotechnology, cancer, cell cycle, cell signalling, climate change, computational biology, development, developmental biology, {DNA}, drug discovery, earth science, ecology, environmental science, Evolution, evolutionary biology, functional genomics, genetics, genomics, geophysics, Immunology, interdisciplinary science, life, marine biology, materials science, Medical research, medicine, metabolomics, molecular biology, molecular interactions, nanotechnology, Nature, neurobiology, neuroscience, palaeobiology, pharmacology, physics, proteomics, quantum physics, {RNA}, science, science news, science policy, signal transduction, structural biology, systems biology, transcriptomics},
18 pages = {711--716},
19 file = {Full Text PDF:/home/fabio/university/papers/zotero/storage/T7UGN8ID/Watts et al. - 2009 - Architecture and secondary structure of an entire .pdf:application/pdf}
20 }